APC and cancer: Exome sequencing reveals considerable coding sequence polymorphism in genes encoding the BIM1 ortholog MAPRE/EB1, and in APC, and other microtubule end‐interacting proteins in the human population (Fu et al, 2013), raising the possibility that different allelic forms of microtubule end proteins might have different quantitative effects on variability in cell decisions in response to signals, and so affect cancer incidence.