Further support for its tumor suppressor function has come from the finding that SNPs G446A (W149X) and T442C (C148R) in the ARL11 gene are associated with familial risk for chronic lymphocytic leukemia (CLL)6 and for breast, prostate, and colorectal cancers (9, –, 15). Here, ARL11 is linked to B-cell chronic lymphocytic leukemia.