In addition, analysis of CIC-DUX4 fusions in specific sarcomas show that fusion with the C-terminal 80 amino acids from 4q35-encoded DUX4-FL is sufficient to convert CIC into a transcriptional activator (Italiano et al., 2012; Kawamura-Saito et al., 2006). This evidence concerns the gene DUX4 and sarcoma.