Since we observed increased recognition of 8-11mer 4T1 peptides by T cells from vaccinated animals, and initial immunohistochemistry experiments suggesting a greater role for CD3 + CD8+ cells than CD3 + CD4+ cells for tumor control in this model (Fig. 1 d,e; Additional file 2: Figure S1A,B), we next sought to confirm the role of CD8+ T cells with an enriched population of CD8+ T cells. Here, CD4 is linked to neoplasm.