In addition to the overall trends we observed between IgG and CD8+ responses, we were struck that minimal peptides from Wdr33:H13Y – a mutation site with strong preexisting IgG signals in naïve animals – were recognized regularly in vaccinated animals by IgG and produced large increases in CD8+ T cell recognition of both 4T1 tumor and Wdr33:H13Y peptides. This evidence concerns the gene CD8A and neoplasm.