The remaining three patients had Netherton syndrome (one case due to SPINK5 mutations), erythrokeratoderma (one case due to GJB3 mutation), and KLICK (keratosis linearis with ichthyosis congenita and sclerosing keratoderma) syndrome (one case carrying POMP mutation). Here, SPINK5 is linked to erythrokeratoderma.