Previous studies have shown that MMP2 activates integrin αvβ3 resulting in cellular invasion [45]; similarly MMP-9 has been shown to enhance metastatic capacity through activation of αvβ3 in breast cancer cell lines [46] and αvβ6 integrin activation has been shown to promote invasion of squamous cell carcinoma cells [45]. Here, MMP2 is linked to squamous cell carcinoma.