When plasma levels of filariasis composite antigen specific IgM were considered both Loa loa microfilaraemic HIV-1 negative (in Fig 2a compare HIV−/MF− with HIV−/MF+) and positive (Fig 2b compare HIV+/MF− with HIV+/MF+) individuals showed significantly higher plasma levels (P < 0.001) vis a vis microfilaraemia negative individuals (Fig 2 a & b). This evidence concerns the gene CD40LG and filariasis.