An increased immune cell infiltrate gene expression signature in ccRCC in comparison to PRCC and ChRCC has been elucidated by several studies, including importance of single gene markers such as PDCD1 (PD1) and CD247 (PDL1) (Chen et al., 2016; Geissler et al., 2015). The gene discussed is CD247; the disease is nonpapillary renal cell carcinoma.