KDM5C and nonpapillary renal cell carcinoma: Mutations of SWI/SNF complex genes, including PBRM1, ARID1A, and SMARCA4, were the most common chromatin remodeling complex alterations within ccRCC (47.1%), followed by mutation of the histone methyltransferases including SETD2 and MLL3 (23.8%), the histone demethylases including KDM5C (13.0%), the BAP1/ASXL1 histone de-ubiquitinase complex (12.1%), and the histone acetyltransferases (4.8%), compared with frequencies of 24.1%, 23.7%, 17.3%, 6.8%, and 7.5%, respectively, in PRCCs (Figure 2D).