CDKN2A alteration provided the sole example of a change that correlated with decreased survival across the entire cohort (p < 0.0001) and in each major histologic subtype, ccRCC (p < 0.0001), type 1 PRCC (p = 0.0067), type 2 PRCC (p = 0.0006), and ChRCC (p = 0.0018) (Figure 2C). This evidence concerns the gene CDKN2A and nonpapillary renal cell carcinoma.