This correlated with increased expression of the pyruvate dehydrogenase complex (PDC) activation genes in ChRCC, that would help fuel the Krebs cycle and oxidative phosphorylation, and the increased expression of PDC suppression genes in ccRCC, which would result in glycolysis-dependent energy production (Figures 5B and S4A). Here, PDC is linked to nonpapillary renal cell carcinoma.