PRCC and nonpapillary renal cell carcinoma: The RNA metabolic process and the mitotic cell cycle signature was specifically increased in ccRCC (p = 5 × 10−26 and p = 5 × 10−25, respectively), while an increased amino acid metabolic process signature (p = 4 × 10−35) and retention of cilium signature (p = 3 × 10−140) was unique to PRCC (Figure 4B).