TP53 and cancer: In total, 1,607 genes harbor SCMs, with 248 of them having more than one mutation, including TP53, GATA3, ATRX, and NF1. Recurrent SCMs were found in TP53, GATA3, DDX5, KDM6A, PTEN, SETD2, SMAD4, BCOR, SPOP, and BAP1, suggesting an association with cancer development.