The discrepancies between PD-L1 expression in germinomas among studies might be attributable to the use of primary antibodies from different manufacturers or different immunoreactivities between the manual operation in our study and the automated staining system used in the study by Aoki et al. Taken together, previous investigations into the same category of pathology and our study of 24 patients offer positive confirmation of the frequent expression of PD-L1 in intracranial germinoma. The gene discussed is CD274; the disease is brain germinoma.