Although, SAA has been shown to play an important role in host defense [11, 27], it’s persistently high concentrations (>1000 nM) could promote injury to tissues and cells during chronic inflammatory conditions, such as joint destruction in rheumatoid arthritis (RA) [21, 28], development of atherosclerosis [29, 30], tumour pathogenesis [31] and especially reactive AA amyloidosis [32]. This evidence concerns the gene SAA2 and rheumatoid arthritis.