HMGB1 and hepatocellular carcinoma: Wang et al. reported the effects of four HMGB1 SNPs (rs1412125, rs1045411, rs2249825, and rs1360485) on the susceptibility and development of hepatocellular cancer and results indicated that carriers with TT genotype had a higher risk of distant metastasis compared with individuals carrying at least one C allele for rs1412125 polymorphism [31].