The NPRBO prepared from Khao’ Gam Leum-Phua showed the highest inhibitory activity on nitric oxide and iNOS production in LPS/IFN-γ-stimulated RAW 264.7 cells and also exerted the highest inhibitory activity on COX-2 production in both colorectal cell lines, i.e., HT-29 adenocarcinoma cells and HCT116 carcinoma cells. The gene discussed is IFNG; the disease is adenocarcinoma.