The 2016 revised World Health Organization (WHO) lymphoma classification recognizes four different entities: systemic ALK-positive ALCL (ALK+ ALCL), systemic ALK-negative ALCL (ALK− ALCL), primary cutaneous ALCL (pC-ALCL), and the provisional entity breast implant-associated ALCL (BI-ALCL) [1]. This evidence concerns the gene ALK and anaplastic large cell lymphoma.