Of note, DUSP22- and TP63-rearrangements are not specific for systemic ALK− ALCL, and can be present in pC-ALCL and other subsets of PTCL; however, in the setting of systemic ALK− ALCL, detection of these translocations can be useful to predict the outcome of the disease and may influence therapeutic strategies [122]. This evidence concerns the gene ALK and anaplastic large cell lymphoma.