ALB and neoplasm: Moreover, since human serum albumin (HSA) does not just load hydrophobic diagnostic and therapeutic agents but also be modified and labeled by radionuclides because of the functional groups of HAS, such as carboxyl, amino, phenolic hydroxyl, and thiol groups [103,104,105], one of the recent studies mixed PTX with 131I-labeled HAS to develop a nanomedicine, which could prolong blood circulation time, increase the drug concentration in tumor cells and penetrate tumors more effectively compared with any therapy alone, inhibiting the tumor growth significantly (see Figure 3) [106].