For instance, Zhang et al. showed that targeted lipid-calcium-phosphate nanoparticles loaded with gemcitabine monophosphate (GMP) and VEGF siRNA improved therapeutic response supported by eightfold reduction of cancer cell proliferated, significant inhibition of tumor growth and little toxicity in vivo, compared with sole chemotherapy or siRNA therapy in human non-small–cell lung cancer (NSCLC) [124]. Here, VEGFA is linked to cancer.