Compared with healthy controls, fewer circulating CD3+ CD45RA+naïve (Tnaïve) and CD4+ CD25−convention (Tconv) T-cells were found [94]; a significantly higher percentage of CD25+ Treg cells from both the CD4+ and CD8+ lineages were found in PBMCs and TILs from NPC patients; and IL-17-producing (CD8+ T17) cells were detected at lower levels in NPC patients than in healthy controls [94,109]. Here, CD4 is linked to nasopharyngeal carcinoma.