Activation of mitochondrial antiviral-signaling protein (MAVS), interferon-regulatory factors (IRF) 3 and 7, and production of type I interferon (IFN-I) have been found to play an important role in the innate immune system’s response to viral infection, by controlling the virus replication, the liver damage and the progressive death in mice experimental models [46]. This evidence concerns the gene MAVS and viral infectious disease.