That TLRs may play an important role in HTN is supported by the finding that inhibiting TLR with neutralizing antibodies resulted in BP reduction and downregulation of NF-κB, ICAM1, chemokines, and cytokines.66,67 It was previously reported that eliciting the RR through a variety of interventions downregulates NF-κB activity, and in this study, this effect has been repeated. The gene discussed is NFKB1; the disease is hypertensive disorder.