PIK3R1 and hypertensive disorder: This analysis identified multiple nuclear transport, cell cycle, protein kinase cascade, and insulin receptor signaling pathway-related genes (NUP43, NUP50, NUPL1, NUP188, RANBP2, TPR, POM121, NUP153, CTNNB1, PIP5K1C, PIK3R1, MAPK8, PIK3CB, PIK3CD, and JUN) as top genes that may be critically involved in BP response after an RR intervention in HTN patients (Fig. 6D).