TLR8 and hypertensive disorder: Analysis of the 84 downregulated genes of the RR HTN Responder Signature predicted inhibition of multiple immune system molecules [e.g., CD2, several members of the Toll-like receptor (TLR) family (TLR4, TLR7, TLR8, TLR9), NFATC2, nuclear factor-κB (NF-κB) (complex), IFNG, CD40LG, tumor necrosis factor (TNF), interleukin (IL)-15, IL-18, IL-2, IL-3] to be responsible for reduced expression of these downstream targets, suggesting that the RR blunts inflammatory and immune processes through reduced activity of this set of regulators, most interestingly NF-κB (Fig. 7A).