Similarly, regulator analysis of the 88 upregulated genes from the RR HTN Responder Signature revealed that activation of several cell growth and immune system molecules (e.g., transforming growth factor-β1, T cell receptor, vascular endothelial growth factor, and oncostatin M) and inhibition of extracellular matrix-related molecules (e.g., COL18A1 and Mir124-3p) (Fig. 7B) may be involved in increased expression of these genes. The gene discussed is COL18A1; the disease is hypertensive disorder.