PRKN and Parkinson disease: Additionally, activation of non-canonical mitophagy may provide an alternative avenue to restore mitochondrial function in PD as several proteins such as Fun14 domain-containing protein 1 (FUNDC1) and autophagy and beclin 1 regulator 1 (Ambra1) displayed an ability to modulate mitophagy in a PINK1/Parkin-independent manner [95].