On the other hand, a lack of endogenous CGRP release may enhance cardiovascular disease as shown in CGRP knockout mice [53] and by the finding that a long-acting CGRP agonist benefits cardiovascular dysfunction, including heart failure in the mouse, and CGRP administration is beneficial in human heart failure and other vascular diseases [19, 54, 55]. Here, CALCA is linked to cardiovascular disorder.