In a glioma-specific analysis, it was found that nearly all tumors with the ‘phase I event’ + 7/− 10 or ‘phase II event’ 1p/19q-codeletion have TERT promoter mutations, whereas not all TERT promoter mutant gliomas have + 7/− 10 or 1p/19q-codeletions, which may indicate that TERT promoter mutations even precede + 7/− 10 and 1p/19q-codeletions [34]. Here, TERT is linked to central nervous system cancer.