These studies are complemented by data from an LPS model of lung injury showing that Tregs suppress fibrocyte recruitment and fibrosis via interruption of the chemokine C-X-C motif ligand 4/stromal cell-derived factor 1 (CXCL4/SDF1) axis (156), but promote fibroblast activation via production of PDGFβ in a model of silicosis (157). Here, CXCL12 is linked to silicosis.