ACHE and early-onset autosomal dominant Alzheimer disease: In particular, huperzine A (Wang et al., 2006), a novel acetylcholinesterase (AChE) inhibitor derived from the Chinese medicinal herb Huperzia serrata, has been used to treat Alzheimer's disease and Youyou Tu was awarded the Nobel Prize in Physiology or Medicine in 2015 for her major contribution to the discovery of artemisinin (Tu, 2011).