Finally, the expression of HSP90, a central player in the control of proteostasis, increases under stress conditions (as ROS accumulation upon oxidative stress) and, it is exploited by cancer cells to support the stability and the aberrant activity of oncoproteins overexpressed or mutated in malignancy including HER2, BCR-ABL, and EGFR (45, 52). Here, ERBB2 is linked to cancer.