These results also go in parallel with previous studies targeting CLDN1, where monoclonal antibodies against CLDN1 inhibited HCV entry and all HCV related signaling events (Mailly, Xiao et al., 2015; Yamashita et al., 2015), and were also effective in hindering infection by all major genotypes of HCV (Fofana et al., 2010). The gene discussed is CLDN1; the disease is infection.