The correlation between the regulation of CLDN1 expression by microRNAs and HCV infectivity was then assessed by forcing the expression of both miRNAs, miR-155 and miR-182, in Huh7 cells followed by infection with JFH1 and ED43/JFH1 HCVcc and evaluation of the viral infectivity by quantifying intracellular viral particles. The gene discussed is CLDN1; the disease is infection.