Both proteins play a crucial role in diverse mechanisms involved in immunity, since their mutants present impaired PTI, SAR and increased susceptibility to Pst DC3000, B. cinerea and A. brassicicola. In fact, similar to sdg8 mutant, sdg25 presents a misregulation in the expression of defense genes and markers in response to the infection of the fungal and bacterial pathogen, including chitinases, glucanases, peroxidases, defensins, PR1, PDF1.2, and BIK1 (Botrytis-induced kinase 1). Here, TMEM37 is linked to infection.