SYK and Arthritis: Though it is at present incompletely understood how Syk within neutrophils participates in autoantibody-induced arthritis development, our prior studies showing defective release of proinflammatory mediators by Syk-deficient neutrophils despite normal intrinsic migratory capacity of the cells (17, 19, 31) suggest that Syk, similar to Src-family kinases (29), participates in the amplification of neutrophil recruitment by neutrophil-derived proinflammatory mediators (44).