FOXP3 and graft versus host disease: Clinical trials with freshly isolated or ex vivo expanded FoxP3+ (127–130) or Tr1 cells (ALT-TEN trial) (131) (from umbilical cord blood or peripheral blood) as a cellular therapy given at or shortly before/after transplantation have been carried out for tolerance to graft-versus-host disease (GvHD) in patients undergoing allo-HSCT for hematological malignancies.