In cervical cancer cells, upregulated miR-130a directly targeted the 3′ UTR of TNF-α and reduced its expression, and then downregulated TNF-α-activated NF-κB activity and enhanced miR-130a expression by a negative feedback loop of NF-κB/miR-130a/TNF-α/NF-κB (51). The gene discussed is NFKB1; the disease is cervical carcinoma.