SOCS1 and Familial prostate cancer: Similarly, the expression of miR-210-3p was also elevated in prostate cancer cells, particularly in bone-metastatic prostate cancer cells, and it was directly targeted multiple negative regulators of the NF-κB signaling pathways, including suppressor of cytokine signaling 1 and tumor necrosis factor alpha induced protein 3 interacting protein 1, resulting in constitutive activation of the NF-κB signaling, and promoting EMT of bone-metastatic prostate cancer cells (61).