Moreover, keratin filament retraction is a morphological hallmark in pemphigus pathogenesis and correlates with loss of intercellular adhesion, depletion of Dsgs from the cell membrane and is interconnected with several signaling pathways known to be crucial for pemphigus such as PKC and p38MAPK (11, 15, 25). The gene discussed is PRRT2; the disease is pemphigus.