ITGAM and neuromyelitis optica: To investigate the inflammation and immune response in the brain of WT and IL-15tg mice, we used H&E staining (Figures 4A,B) and flow cytometry to detect the subsets of leukocytes, as well as microglia, the gating strategy as in Figure 4C. We did not observe a significant difference in the number of CD45int/CD11b+ (microglia) in the brain between WT and IL-15tg mice after NMO induction.