Henry and coworkers reported a single intratracheal injection of OVA-pulsed, IL-10-transduced DCs to prevent eosinophilic airway inflammation, AHR, production of mucus, antigen-specific IgE and immunoglobulin G1 (IgG1) antibodies, and IL-4 as well as IFN-γ production in a mouse model of experimental asthma (Figure 2B) (4). The gene discussed is IGHE; the disease is asthma.