Using a novel Medical-In silico approach, this study shows (i) that HS induces necroptosis in cardiomyocytes by phosphorylation (activation) of RIP3, (ii) suggest that HS may have the potential as a therapeutic target in trauma- or sepsis-associated cardiomyopathy, and (iii) indicate that this proof-of-concept is a first step toward simulating the extent of activated components in the pro-apoptotic pathway induced by HS with only a small data set gained from the in vitro experiments by using machine learning algorithms. This evidence concerns the gene RIPK3 and cardiomyopathy.