miR-223 regulates erythrocyte membrane protein band 4.1 like 3 (EPB41L3) gene, known to be linked to atherosclerosis, while miR-126 regulates a gene that is strongly linked to endothelial dysfunction and atherosclerosis as vascular cell adhesion molecule 1 (VCAM-1), therefore indicating that platelet-derived miRNAs have an impact on the regulation of key genes associated with CVD (5). The gene discussed is VCAM1; the disease is endothelial dysfunction.