NFKB1 and Alzheimer disease: It is remarkable that of the few GI tract-derived microbes so far studied that all appear to be employing an NF-κB-miRNA-146a signaling pathway that promotes amyloidogenesis, apoptosis, inflammatory neurodegeneration, synaptic and neurotropic defects—all of which are characteristic aspects of AD-type neuropathology (Figure 1) (85–87).