CDKL3 and cholangiocarcinoma: As CDKL3 was previously shown an important role in the proliferation and cell cycle regulation in HeLa, HEK-293, CHO and MDCK cells (Yee et al., 2003; Jaluria et al., 2007), we sought to verify whether the anticancer effect of curcumol in CCA cells is also mediated through CDKL3.