ROS have also been demonstrated to contribute to elevated BP in hypertensive animal models where a greater contribution of the central RAS is apparent, including AngII induced hypertension (Zimmerman et al., 2004; Campese et al., 2005), Dahl salt sensitive hypertensive rats (Fujita et al., 2007) and high salt diet induced hypertension in SHR (Koga et al., 2008). Here, AGT is linked to hypertensive disorder.