Reduce cell proliferation, cell stemness, limit invasion, induce autophagy, and regulate GSC plasticity and cancer immunity by:– downregulating Sox1, Sox2, Nestin, Ki67, CD44– inhibiting PI3K/Akt/mTOR signaling pathway– increasing phospho-c-Jun and cytochrome c– regulating NADPH oxidase-mediated ROS generation. This evidence concerns the gene NES and cancer.