A phenothiazine, CPZ, was demonstrated by Oliva et al. to inhibit mitochondrial cytochrome c oxidase (CcO) in chemoresistant glioma cells and GSCs when CcO subunit 4 isoform 1 (COX4-1) is present, but not COX4-2 (Oliva et al., 2017). Here, RYR1 is linked to central nervous system cancer.