KCNA3 and Anxiety: While these metrics implicated an increased anxiety level in the Kv1.3−/− mice, there was not a significant difference in exploratory behavior as assessed by total number of transitions between boxes (Figure 1F; 2-way ANOVA, sex: p = 0.057; genotype: p = 0.138; interaction: p = 0.382) although there was a trend that the Kv1.3−/− moved less in this assay and particularly for that of females.