In comparison to treatments in which insulin is intranasally delivered to phosphorylate its Kv1.3 substrate, which is known to decrease mean open time of the channel (Fadool et al., 2011), mice with reduced Kv1.3 activity but not targeted deletion have anxiolytic-like behaviors or reduced anxiety in terms of more time in the light chamber of the LDB as well as increased time in open arms of the EPM (Marks et al., 2009). This evidence concerns the gene KCNA3 and Anxiety.