Mutations in KCNJ2 leading to loss-of-function of Kir2.1 have been linked with Andersen-Tawil syndrome, a cardiovascular disease characterized by QT prolongation, predisposition to cardiac tachyarrhythmias (Donaldson et al., 2004) as well as skeletal abnormalities, mood disorders and seizures (Guglielmi et al., 2015). This evidence concerns the gene KCNJ2 and mood disorder.