KCNJ2 and cardiovascular disorder: Mutations in KCNJ2 leading to loss-of-function of Kir2.1 have been linked with Andersen-Tawil syndrome, a cardiovascular disease characterized by QT prolongation, predisposition to cardiac tachyarrhythmias (Donaldson et al., 2004) as well as skeletal abnormalities, mood disorders and seizures (Guglielmi et al., 2015).