ADORA2A and Huntington disease: T1-11 is a dual-function adenosine compound with moderate affinity toward A2AR and an adenosine transporter (equilibrative nucleoside transporter 1, ENT1) that has been demonstrated to ameliorate motor degeneration in HD mice (Huang et al., 2011) and SCA3 (Chou et al., 2015) as well as to improve neurovisceral symptoms in Niemann-Pick type C disease (Ferrante et al., 2017).