Bile acids also show a role in the regulation of the metabolic pathway through its binding to specific receptors like Farnesoid X receptor (FXR) involved in cholesterol production, glucose metabolism and bile acid synthesis or TGR5 (G-protein coupled receptor specific for bile acids) involved in energy expenditure in brown adipose tissue, obesity prevention and insulin resistance. The gene discussed is NR1H4; the disease is obesity due to melanocortin 4 receptor deficiency.