Abnormalities in the interaction between mGlu5 receptors and Homer have been described in animal models of monogenic autism (Ronesi et al., 2012; D'Antoni et al., 2014; Pignatelli et al., 2014; Guo et al., 2015, 2016), suggesting that Homer expression and function lies at the core of postsynaptic mechanisms underlying learning and memory processes and cognitive functions. Here, HOMER1 is linked to autism.