Exploring these data further in a post-hoc analysis, we now observed patterns in the association between ADAMTS13 and risk of ischaemic stroke, similar to those with dementia in the current study (HR [95% CI] per SD decrease in ADAMTS13 for risk of ischaemic stroke in those free of (pre-)diabetes: 1.19 [1.04–1.36], versus in those with (pre-)diabetes: 0.94 [0.79–1.11]). The gene discussed is ADAMTS13; the disease is diabetes mellitus.