In conclusion, while the combinatorial use of DIS and CBX was originally envisaged to target different cell populations within the tumour, and therefore the requirement for those two substances was merely not to antagonize each other, we found that the combination of DIS with CBX had a major inhibitory effect on survival and cell cycle proteins involved in proliferation and apoptosis (Fig. 3 and Fig. S5). The gene discussed is PROS1; the disease is neoplasm.