HAT1 and esophageal squamous cell carcinoma: In esophageal squamous cell carcinoma, HAT1 was an important determinant to regulate the proliferation of human cancerous cells and knockdown of HAT1 induced a G2/M cell cycle arrest, which was associated with the disruption of cell cycle-related events suggesting that HAT1 played an important role in esophageal carcinoma and could potentially be used as a novel therapeutic target56.