Our data revealed that RPL15 was significantly up-regulated in PAH progression, whereas, RPL23a, RPL35a, RPL17, RPL31, RPS13, RPS4, RPS3a are noticeably decreased in PAH rats, and such expressional were significantly restored by osthole treatment, as RPL15 were reported to promote cell proliferation, which is a prognostic biomarker in pancreatic ductal adenocarcinoma24. Here, RPS13 is linked to pulmonary arterial hypertension.