Our data revealed that RPL15 was significantly up-regulated in PAH progression, whereas, RPL23a, RPL35a, RPL17, RPL31, RPS13, RPS4, RPS3a are noticeably decreased in PAH rats, and such expressional were significantly restored by osthole treatment, as RPL15 were reported to promote cell proliferation, which is a prognostic biomarker in pancreatic ductal adenocarcinoma24. This evidence concerns the gene RPL15 and pulmonary arterial hypertension.