Human patients with APOC2 or LPL deficiency, or deficiency in glycosylphosphatidylinositol-anchored high-density lipoprotein-binding protein 1 (GPIHBP1), the LPL vascular anchor, develop severe hypertriglyceridemia and chylomicronemia1, 3. This evidence concerns the gene GPIHBP1 and hypertriglyceridemia.