Specifically, the mRNA levels of ABCA1 were significantly downregulated in all BC cells in response to atorvastatin (Fig. 2C,D and Supplementary Fig. S3B for relative ABCA1 expression), but similar to LDLR, the extent of downregulation could not consistently discriminate between treatment-sensitive and insensitive BC cells (p = 0.735; Fig. 2D). This evidence concerns the gene LDLR and breast cancer.