HMGCR and breast cancer: Since the levels of HMGCR expression and LD accumulation were significantly differentially altered by atorvastatin in a somewhat consistent trend between the sensitive and insensitive BC cells, we performed a SAM analysis to further explore whether these observations could be extended to include any other gene(s) involved in the global lipid metabolism pathway (GO:0006629), given the null associations observed for the specific investigations for LDLR, ABCA1 and ABCG1 expression and response to treatment.