B2M and cancer: Josson et al. reported that hemochromatosis (HFE) protein, a non-classical MHC class I member, interacts with B2M to regulate iron homeostasis and control EMT of cancer cells via interaction with TFRC 1 (transferrin receptor complex 1) and suggested that B2M/HFE interactions are important for the secreted B2M-mediated EMT16.